cIAP-2 protein is upregulated by human papillomavirus in oropharyngeal cancers: role in radioresistance in vitro
This study demonstrated for the first time a positive relationship between HPV presence and cIAP2 levels in OPCs. Additionally, cIAP2 knocking down sensitizes HNC cells to apoptosis promoted by radiation. Therefore, cIAP2 is a potential therapeutic target for radiation in HPV-driven HNC.
Authors
- Felipe Carvajal (ORCID: https://orcid.org/0000-0002-4576-9310)
- Enrique Boccardo (ORCID: https://orcid.org/0000-0003-1900-0273)
- Paul Boettiger
- Francisco Aguayo (ORCID: https://orcid.org/0000-0002-9619-7535)
- Carolina Oliva (ORCID: https://orcid.org/0000-0003-2202-1948)
- Iván Gallegos
- Diego Carrillo-Beltrán
- Julio Osorio (ORCID: https://orcid.org/0000-0003-2326-4247)
- Claudio Mancilla-Miranda
Institutions
- Austral University of Chile (CL)
- Universidade de São Paulo (BR)
- University of Tarapacá (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Instituto Nacional del Cáncer (CL)
- Millennium Institute on Immunology and Immunotherapy (CL)
- University of Chile (CL)
Publication Details
- Journal
- Infectious Agents and Cancer
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13027-024-00609-z
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Investigación y Desarrollo