The cytotoxic activities of the major diterpene extracted from Salvia multicaulis (Bardakosh) are mediated by the regulation of heat-shock response and fatty acid metabolism pathways in human leukemia cells
Candesalvone B methyl ester isolated from S. multicaulis exerted cytotoxicity by affecting apoptosis, cell division, and modulation of expression levels of genes contributing to the heat stress signaling and fatty acid metabolism pathways that could relieve drug resistance of leukemia cells.
Authors
- Ahmed Abdelsadik (ORCID: https://orcid.org/0000-0002-4782-6681)
- Mona Dawood (ORCID: https://orcid.org/0000-0002-6312-1999)
- Mohamed‐Elamir F. Hegazy (ORCID: https://orcid.org/0000-0002-0343-4969)
- Heba K. Nabih
- Thomas Efferth (ORCID: https://orcid.org/0000-0002-2637-1681)
- Rümeysa Yücer (ORCID: https://orcid.org/0000-0002-9678-3323)
- Nasim Shahhamzehei
- Taha A. Hussien (ORCID: https://orcid.org/0000-0002-4979-4986)
- Nuha Mahmoud (ORCID: https://orcid.org/0000-0002-2018-5204)
- Mahmoud A. A. Ibrahim (ORCID: https://orcid.org/0000-0003-4819-2040)
- Sabine M. Klauck (ORCID: https://orcid.org/0000-0001-7293-9920)
- Mohamed A. M. Atia (ORCID: https://orcid.org/0000-0003-2462-1269)
- Mohamed Elbadawi
Institutions
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Al-Neelain University (SD)
- National Center for Tumor Diseases (DE)
- Agricultural Genetic Engineering Research Institute (EG)
- National Research Centre (EG)
- Agricultural Research Center (EG)
- Sphinx University (EG)
- Aswan University (EG)
- Minia University (EG)
- Assiut University (EG)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.phymed.2024.156023
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Alexander von Humboldt-Stiftung