The oncogenic ADAMTS1–VCAN–EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma
Our results collectively uncover a novel cyclic axis involving ADAMTS1-VCAN-EGFR, which significantly contributes to RCC invasion and resistance to anoikis, thus presenting a promising therapeutic target for RCC metastasis.
Authors
- Kuo-Hao Ho (ORCID: https://orcid.org/0000-0001-8003-7468)
- Chih‐Ying Chu (ORCID: https://orcid.org/0000-0001-7318-8372)
- Wei‐Jiunn Lee (ORCID: https://orcid.org/0000-0002-4003-9503)
- Yu‐Ching Wen (ORCID: https://orcid.org/0000-0002-0256-1448)
- Feng-Ru Lai
- Ming‐Hsien Chien (ORCID: https://orcid.org/0000-0002-0084-7231)
- Ji‐Qing Chen (ORCID: https://orcid.org/0000-0002-1598-8811)
- Yung‐Wei Lin
- Yi-Chieh Yang
Institutions
- Dartmouth College (US)
- Taipei Medical University Hospital (TW)
- Tungs' Taichung MetroHarbor Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s11658-024-00643-0
- Citations
- 8
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- Taipei Medical University
- Wan Fang Hospital