Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures
Our results reveal a spatial association between the epileptogenic focus and tau deposition, amyloid deposition, and neurodegeneration in early clinical stages of AD. Within the limitations of a cross-sectional study with small sample sizes, these findings contribute to our understanding of the clinicopathologic heterogeneity of AD, demonstrating an association between focal epilepsy and lateralized pathology in AD.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Stephanie S. Buss (ORCID: https://orcid.org/0000-0002-9912-063X)
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Rani A. Sarkis (ORCID: https://orcid.org/0000-0001-8291-7864)
- Eliezer J. Sternberg
- Anand Viswanathan (ORCID: https://orcid.org/0000-0001-5398-1816)
- Danielle V. Mayblyum
- Kyle R. Pellerin (ORCID: https://orcid.org/0009-0000-4856-7602)
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Alice Lam (ORCID: https://orcid.org/0000-0001-7754-4637)
- Stephanie Hsieh (ORCID: https://orcid.org/0000-0002-6929-6810)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-5916-6043)
Institutions
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1212/wnl.0000000000209920
- Citations
- 22
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.48
Funders
- Alzheimer's Association
- American Academy of Neurology
- National Institutes of Health