Alkoxylation of Ketone Mediated by <i>N</i>‐Heterocyclic Carbene Borane and Sulfuric Acid in Alcohol
Abstract In this study, a novel method for the alkoxylation of ketones has been developed, employing sulfuric acid and N‐heterocyclic carbene boranes (NHC−boranes). The ketones are reduced using NHC−borane (diMe‐Imd‐BH 3 ) and subsequently alkoxylate with sulfuric acid in alcohol solvents. Due to the stability of NHC−borane in the presence of both moisture and air, this reaction emerges as an effective and accessible approach for organic synthesis.
Authors
- Shau‐Hua Ueng (ORCID: https://orcid.org/0000-0003-3287-0193)
- Po-Wei Chang
- Sudhakar Dattatray Tanpure (ORCID: https://orcid.org/0000-0001-9677-2889)
Institutions
- National Health Research Institutes (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1002/ajoc.202400436
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Educational Development Foundation
- National Health Research Institutes
- National Science and Technology Council