Sodium octanoate mediates GPR84-dependent and independent protection against sepsis-induced myocardial dysfunction
Our study demonstrates that SO exerts protective effects against SIMD through both GPR84-mediated anti-inflammatory and antioxidant actions and GPR84-independent enhancement of myocardial energy metabolism, possibly mediated by MCAD.
Authors
- Chenghao Wu (ORCID: https://orcid.org/0000-0001-5449-9765)
- Zhaocai Zhang (ORCID: https://orcid.org/0000-0002-4709-066X)
- Huiming Zhong (ORCID: https://orcid.org/0000-0002-1106-9682)
- Jiawei Tao
- Xiangkang Jiang
- Jiefeng Xu (ORCID: https://orcid.org/0000-0001-5597-0838)
- Ziwei Chen (ORCID: https://orcid.org/0009-0001-8242-3853)
- Mao Zhang (ORCID: https://orcid.org/0000-0001-7919-8213)
- Wenbin Zhang (ORCID: https://orcid.org/0000-0002-9295-1019)
- Jinbo Zhang (ORCID: https://orcid.org/0000-0001-6465-5426)
- Jingyuan Yang (ORCID: https://orcid.org/0009-0008-0880-5504)
- Jiantao He
- Yao Lin
- Ruojie Zhu
Institutions
- Zhejiang Hospital (CN)
- Air Force General Hospital PLA (CN)
- The First People's Hospital of Wenling (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.biopha.2024.117455
- Citations
- 7
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 2.50