Tryptophan-rich diet and its effects on Htr7+ Tregs in alleviating neuroinflammation and cognitive impairment induced by lipopolysaccharide
Our research revealed the ability of Htr7<sup>+</sup> Tregs to mitigate neuroinflammation and prevent neuronal damage by suppressing the infiltration of CD8<sup>+</sup> T cells into the brain and excessive activation of microglia, thereby ameliorating LPS-induced cognitive impairment. These insights may offer novel therapeutic targets involving Tregs for neuroinflammation and cognitive impairment.
Authors
- Mingru Zhang (ORCID: https://orcid.org/0000-0002-4514-9824)
- Yanhong Liu (ORCID: https://orcid.org/0000-0002-7349-5871)
- Luyu Liu (ORCID: https://orcid.org/0000-0002-6684-5570)
- Jingsheng Lou (ORCID: https://orcid.org/0000-0002-0295-5105)
- Weidong Mi (ORCID: https://orcid.org/0000-0002-3546-0440)
- Yanxiang Li (ORCID: https://orcid.org/0000-0002-5248-6757)
- Dinghao Xue (ORCID: https://orcid.org/0000-0002-9727-4133)
- Hao Li (ORCID: https://orcid.org/0000-0002-9759-2537)
- Jingjing Liu (ORCID: https://orcid.org/0000-0001-7558-5558)
- Long Wang (ORCID: https://orcid.org/0000-0001-5600-8157)
- Xu Guo (ORCID: https://orcid.org/0009-0000-1625-5671)
- Qiang Fu (ORCID: https://orcid.org/0000-0003-1185-2340)
- Jiangbei Cao (ORCID: https://orcid.org/0000-0003-1218-4639)
- Guosong Liao
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- United States Army (US)
- Chinese People's Armed Police General Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12974-024-03239-9
- Citations
- 12
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.89
Funders
- National Natural Science Foundation of China