HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions
Our study leverages spatial gene expression profiling technologies to dissect HCC heterogeneity and identify heterogeneous signaling relationships between cancer cells and their endothelial cells. Future validation and expansion of these findings may validate novel cancer-endothelial cell interactions and related drug targets.
Authors
- Yujin Hoshida (ORCID: https://orcid.org/0000-0001-9430-1426)
- David Tsai Ting (ORCID: https://orcid.org/0000-0002-3261-2322)
- Ann Liu (ORCID: https://orcid.org/0000-0002-0908-3506)
- Michael J. Raabe (ORCID: https://orcid.org/0009-0009-7345-7507)
- Joseph W. Franses (ORCID: https://orcid.org/0000-0002-2517-4950)
- Avril K. Coley (ORCID: https://orcid.org/0000-0002-5858-952X)
- Amaya Pankaj (ORCID: https://orcid.org/0009-0001-7509-7447)
- Irun Bhan (ORCID: https://orcid.org/0000-0002-2163-0488)
- Matthew J. Emmett (ORCID: https://orcid.org/0000-0002-8855-423X)
- Martin J. Aryee (ORCID: https://orcid.org/0000-0002-6848-1344)
- Nova Xu (ORCID: https://orcid.org/0000-0001-6780-1978)
- Chenyue Lu (ORCID: https://orcid.org/0000-0002-7905-2078)
- Cole Nawrocki (ORCID: https://orcid.org/0000-0001-7776-2095)
- Bidish K. Patel
- Cristina R. Ferrone
- Vikram Deshpande
Institutions
- Broad Institute (US)
- California Institute of Technology (US)
- Cedars-Sinai Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Sinai Hospital (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Southwestern Medical Center (US)
- Dana-Farber Cancer Institute (US)
- Southwestern Medical Center (US)
- Massachusetts Institute of Technology (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1097/hc9.0000000000000533
- Citations
- 5
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Pfizer
- AstraZeneca
- Sanofi
- Massachusetts General Hospital
- Incyte
- Ribon Therapeutics
- Iterion Therapeutics
- Moderna
- Eisai
- Servier
- Genentech
- Foundation Medicine