Clinical strategy study on prenatal screening and diagnostic model for Down syndrome
Exploring efficient and easily implementable prenatal screening strategies aims at birth defect prevention and control. However, there have been limited economic evaluations of non-invasive prenatal screening (NIPS) strategies in China. Furthermore, these studies were predominantly confined to local or geographically proximate provinces and lacked universality and representativeness. This study assesses the health economics of current prenatal screening strategies and NIPS as first-line screening programs, analyzing their efficacy to determine an optimal strategy. From the perspective of health economics, cost-effectiveness, cost-benefit, and single-factor sensitivity were conducted for five different screening strategies using a decision tree model. Among pregnant women aged < 35 years who underwent only one screening for foetal Down syndrome (DS), the detection rate, false positive rate and positive predictive value of NIPS for foetuses with DS were superior to those of the other four serological screening methods. Although applying NIPS as first-line screening method yields the highest efficacy and benefits, it currently lacks cost-effectiveness when compared to serological screening and sequential NIPS screening strategies.
Authors
- Shanling Liu (ORCID: https://orcid.org/0000-0001-8788-7991)
- Fene Zou
- Hongqian Liu (ORCID: https://orcid.org/0000-0002-5229-793X)
- Lingling Xing (ORCID: https://orcid.org/0000-0002-2235-6943)
- Daiwen Han
- Kai Zhao
- Quanfang Zhou
- Bin He (ORCID: https://orcid.org/0000-0001-6884-6166)
- Lixing Yuan (ORCID: https://orcid.org/0000-0002-4435-3225)
- Ting Bai (ORCID: https://orcid.org/0000-0001-8337-3272)
- Ling Pang
- Tianyu Xia
- Cechuan Deng (ORCID: https://orcid.org/0000-0002-8511-7990)
- Xiangjin Wei (ORCID: https://orcid.org/0000-0002-1190-5222)
- Wei Luo (ORCID: https://orcid.org/0000-0002-8465-5607)
- Sha Liu (ORCID: https://orcid.org/0000-0002-6710-8126)
- Qian Zhu (ORCID: https://orcid.org/0000-0001-7062-8221)
- Jianlong Liu (ORCID: https://orcid.org/0000-0003-2680-9951)
- Jing Cheng (ORCID: https://orcid.org/0000-0002-0417-3713)
- Yunyun Liu (ORCID: https://orcid.org/0000-0002-5553-1672)
- Jun Tang (ORCID: https://orcid.org/0000-0001-6253-9704)
- Yuan Luo (ORCID: https://orcid.org/0009-0000-1193-4923)
- Xiaosha Jing
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1038/s41598-024-73183-4
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Sichuan Province Science and Technology Support Program
- National Key Research and Development Program of China