Photoinduced Ligand-to-Copper Charge Transfer for Aryl Decarboxylative Allylation, Thiolation, and Bromination
Herein, aryl decarboxylative allylation, thiolation, and bromination reactions via photoinduced ligand-to-copper charge transfer are described. Utilizing inexpensive copper metal, the transformations of various aryl carboxylic acids enable the rapid synthesis of the corresponding alkene, thioether, and aryl bromide derivatives under visible light irradiation, which offers significant synthetic value. The reaction conditions are mild and straightforward, exhibiting a broad substrate compatibility. Furthermore, this method can be applied for the late-stage modification of complex drug molecules.
Authors
- Wujiong Xia (ORCID: https://orcid.org/0000-0001-9396-9520)
- Lin Guo (ORCID: https://orcid.org/0000-0002-2398-0684)
- Chao Yang (ORCID: https://orcid.org/0000-0003-1103-0056)
- Ao-Men Hu
- Jiawen Yin
- Jia‐Lin Tu (ORCID: https://orcid.org/0000-0002-9205-0878)
- Ke Wang (ORCID: https://orcid.org/0000-0002-6194-4000)
Institutions
- Harbin Institute of Technology (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1021/acs.orglett.4c03188
- Citations
- 14
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality
- State Key Laboratory of Urban Water Resource and Environment
- Basic and Applied Basic Research Foundation of Guangdong Province