Diagnosis of <i>Helicobacter pylori</i> infection: serology vs. urea breath test

This study compares the performance of serology with urea breath test in the diagnosis of <i>Helicobacter pylori</i> in a population-level data set and mimics a head-to-head direct comparison as the study population had both tests performed within 2 weeks of each other. This provides new information supporting the use of serology in a diagnostic algorithm. There are several instances where serology could be preferable to patients to rule out disease, despite some guidelines suggesting serology should not be used.