IPNA clinical practice recommendations for the diagnosis and management of children with IgA nephropathy and IgA vasculitis nephritis
IgA nephropathy and IgA vasculitis with nephritis, albeit rare, represent two relatively frequent glomerular conditions in childhood. Compared to adults, pediatric IgA nephropathy has a more acute presentation, most frequently with synpharyngitic macrohematuria and histologically with more intense inflammation and less intense chronic damage. Management of these conditions is controversial and supported by little high-quality evidence. The paucity of evidence is due to the disease heterogeneity, its inter-ethnic variability, and the difficulty of extrapolating data from adult studies due to the peculiarities of the condition in children. IgA vasculitis with nephritis is a kidney manifestation of a systemic disorder, typical of the pediatric age, in which both the diagnosis of kidney involvement and its management are poorly defined, and an interdisciplinary approach is crucial. Both conditions can have a profound and long-lasting impact on kidney function and the global health of affected children. The International Pediatric Nephrology Association has therefore convened a diverse international group of experts from different disciplines to provide guidance on the recommended management of these conditions in children and to establish common definitions and define priorities for future high-quality, evidence-based collaborative studies for the benefit of children.
Authors
- Keisha L. Gibson (ORCID: https://orcid.org/0000-0003-4702-8150)
- Rosanna Coppo (ORCID: https://orcid.org/0000-0003-4713-6282)
- Deirdré Hahn (ORCID: https://orcid.org/0000-0002-2105-146X)
- Melvin Bonilla‐Félix (ORCID: https://orcid.org/0000-0001-8295-0015)
- Koichi Nakanishi (ORCID: https://orcid.org/0000-0001-8681-9129)
- Siah Kim (ORCID: https://orcid.org/0000-0003-3964-2046)
- Dieter Haffner (ORCID: https://orcid.org/0000-0002-9601-7813)
- Mukta Mantan (ORCID: https://orcid.org/0000-0002-6922-6548)
- Susan Samuel (ORCID: https://orcid.org/0000-0003-2224-448X)
- Jonathan Barratt (ORCID: https://orcid.org/0000-0002-9063-7229)
- Yuko Shima (ORCID: https://orcid.org/0000-0003-3944-0110)
- Paul A. Brogan (ORCID: https://orcid.org/0000-0001-6178-6893)
- Marina Vivarelli (ORCID: https://orcid.org/0000-0002-2448-1959)
- Mark Haas (ORCID: https://orcid.org/0000-0002-7181-4664)
- Hernán Trimarchi (ORCID: https://orcid.org/0000-0002-6921-4811)
- Isaac Liu
- Olivia Boyer (ORCID: https://orcid.org/0000-0002-3957-1359)
- A. Alladin
- Ken Pfister
- Zhihong Liu (ORCID: https://orcid.org/0000-0001-6093-0726)
- Qian Shen (ORCID: https://orcid.org/0009-0000-2961-0898)
- Masaki Shimuzu
- Elisabeth M Hodson
- Maher Ahmed Abdel-Hafez
- Marta Adragna
Institutions
- University of North Carolina at Chapel Hill (US)
- Tokyo Medical and Dental University (JP)
- Cedars-Sinai Medical Center (US)
- University of Leicester (GB)
- University of Puerto Rico, Medical Sciences Campus (PR)
- National University of Singapore (SG)
- University of Calgary (CA)
- Wakayama Medical University (JP)
- Université Paris Cité (FR)
- Tanta University (EG)
- Garrahan Hospital (AR)
- Great Ormond Street Hospital (GB)
- Children's Hospital at Westmead (AU)
- University of the Ryukyus (JP)
- Medizinische Hochschule Hannover (DE)
- Maulana Azad Medical College (IN)
- Fondazione Ricerca Molinette (IT)
- Assistance Publique – Hôpitaux de Paris (FR)
- Bambino Gesù Children's Hospital (IT)
- Kidney Health Australia (AU)
- Duke-NUS Medical School (SG)
- Hospital Británico de Buenos Aires (AR)
- Children's Hospital of Fudan University (CN)
- Institut des Maladies Génétiques Imagine (FR)
- University College London (GB)
- Nanjing University (CN)
- University of Guyana (GY)
Publication Details
- Journal
- Pediatric Nephrology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1007/s00467-024-06502-6
- Citations
- 49
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 16.62