The value of surfactant protein a in evaluating the severity and prognosis in community-acquired pneumonia patients
In CAP patients, inverse dose-response correlations exist between serum SP-A levels with severity scores as well as prognosis at admission, suggesting that SP-A may take part in the CAP pathophysiological processes. Moreover, lower serum SP-A on admission is associated with an elevated prognostic risk of mechanical ventilation, the use of vasoactive agents, longer hospital stays, ICU admission, and mortality. Therefore, as a biomarker, SP-A may have the potential to predict the severity and poor prognosis of CAP patients.
Authors
- Hui Zhao (ORCID: https://orcid.org/0000-0003-4090-5720)
- Lin Fu (ORCID: https://orcid.org/0000-0003-1069-3560)
- Qi-Yuan He (ORCID: https://orcid.org/0009-0004-2181-6882)
- You-Peng Deng
- Ying Liu (ORCID: https://orcid.org/0000-0003-2408-3712)
- Jing Sun (ORCID: https://orcid.org/0000-0002-3282-6961)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12890-024-03297-y
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- University Natural Science Research Project of Anhui Province