White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder

This study identified that lesions affecting different WM tracts in MS can result in OAB symptoms and demonstrated the role of the WM in the neural control of LUT functions. By using DTI, the association between OAB symptom severity and WM changes were identified, adding knowledge to the current LUT working model. As MS is predominantly a WM disease, these findings suggest that regional WM involvement, including of the anterior corona radiata, anterior thalamic radiation, superior longitudinal fasciculus, and superior frontal-occipital fasciculus and a non-dominant prevalence in WM, can result in OAB symptoms. OAB symptoms in MS correlate with anisotropy changes in different white matter tracts as demonstrated by DTI. Structural impairment in WM tracts plays an important role in LUT symptoms in MS.

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Publication Details

Journal
Brain Sciences
Published
2024-09-27
DOI
https://doi.org/10.3390/brainsci14100975
Citations
1
Primary Topic
Advanced Neuroimaging Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.40

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article

White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder

Ahmed Toosy, Gloria Castellazzi, Xixi Yang, Claudia A. M. Gandini Wheeler‐Kingshott et al.
1 citations
Brain Sciences
Advanced Neuroimaging Techniques and Applications
0.40
article

White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder

Ahmed Toosy, Gloria Castellazzi, Xixi Yang, Claudia A. M. Gandini Wheeler‐Kingshott, Marios Yiannakas, Carole H. Sudre, Ferrán Prados, Jalesh N. Panicker, Baris Kanber, Jiaying Zhang, Martina D. Liechti, Gwen Gonzales
article en
1 citations

Abstract

This study identified that lesions affecting different WM tracts in MS can result in OAB symptoms and demonstrated the role of the WM in the neural control of LUT functions. By using DTI, the association between OAB symptom severity and WM changes were identified, adding knowledge to the current LUT working model. As MS is predominantly a WM disease, these findings suggest that regional WM involvement, including of the anterior corona radiata, anterior thalamic radiation, superior longitudinal fasciculus, and superior frontal-occipital fasciculus and a non-dominant prevalence in WM, can result in OAB symptoms. OAB symptoms in MS correlate with anisotropy changes in different white matter tracts as demonstrated by DTI. Structural impairment in WM tracts plays an important role in LUT symptoms in MS.

Brain SciencesVol. 14(10)
Universitat Oberta de Catalunya (ES), King's College London (GB), University of Zurich (CH), University of Pavia (IT), Xuan Wu Hospital of the Capital Medical University (CN), Universitätsklinik Balgrist (CH), UK Dementia Research Institute (GB), National Hospital for Neurology and Neurosurgery (GB), University College London (GB)
Medical Research Council
Openalex Percentile: Top 34%
Advanced Neuroimaging Techniques and Applications
0.40
DOIOpen Access PDFOpenAlex
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