Systemic comparison of molecular characteristics in different skin fibroblast senescent models
Each senescent FB model exhibited different characteristics. In addition to showing upregulated expression of natural senescence features, FB-UVB and FB-ATV showed high expression levels of senescence-related genes, including those involved in the SASP, and FB-P30 showed the greatest similarity with FB-E. However, D-galactose-stimulated FBs did not clearly present aging characteristics.
Authors
- Mingyang Wu (ORCID: https://orcid.org/0000-0003-3001-1897)
- Xiaokai Fang (ORCID: https://orcid.org/0000-0003-4423-8873)
- Xu Yao (ORCID: https://orcid.org/0000-0003-3509-4775)
- Shan Zhang (ORCID: https://orcid.org/0009-0004-4913-5579)
- Xiaochun Liu (ORCID: https://orcid.org/0000-0002-0345-6850)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Yang Luo (ORCID: https://orcid.org/0000-0003-2542-3619)
- Yuan Zhou (ORCID: https://orcid.org/0009-0002-2986-1747)
- Xingyu Chen (ORCID: https://orcid.org/0009-0006-6031-2075)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1097/cm9.0000000000003312
- Citations
- 3
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- National Natural Science Foundation of China