Modern biomarkers in IgA vasculitis with nephritis in children

Immunoglobulin A (IgA) vasculitis (IgAV) is the most common form of vasculitis in the pediatric population. From 30% to 60% of children with IgAV are affected by the accumulation of deposits of IgA in the glomeruli and the development of nephropathy in the course of IgA vasculitis with nephritis (IgAVN).<br /> Besides well-known factors such as proteinuria or lower glomerular filtration rate (GFR), the need for the identification of early disease biomarkers was also pointed out. These biomarkers would enable us to predict the disease course in a non-invasive way and focus the therapy on risk stratification. We are searching for markers that will allow us to predict the progress of nephropathy in the course of IgAV or the severity of IgAVN. <br /> The aim of the study is to present the currently known biomarkers in IgAVN. We present the significance of GDIgA1, anti-GDIgA1, the immune complexes Gd-IgA1-anti-Gd-IgA1, FcαRI/CD89, sTfR/CD71, interleukin (IL)-6 and IL-8, KIM-1, MCP1, NAG, UAGT and vanin-1 and metabolomic factors in IgAVN in children.