The interaction between neutrophils and atrial myocytes in the occurrence and development of atrial fibrillation
These findings suggest that neutrophils were polarized into N1 phenotype in AF, TNF-α released from N1 neutrophils contributes to the pathogenesis of AF, via decreasing the APD and LTCC in atrial myocytes through down-regulation of CACNA1C expression.
Authors
- Yan Wang (ORCID: https://orcid.org/0000-0002-7136-9353)
- Yu Duan (ORCID: https://orcid.org/0009-0006-3133-403X)
- Tao Li (ORCID: https://orcid.org/0000-0002-8610-5967)
- Yang Xu (ORCID: https://orcid.org/0000-0002-1074-608X)
- Jie Wan (ORCID: https://orcid.org/0000-0002-6479-4802)
- Mao Yang (ORCID: https://orcid.org/0000-0001-5327-875X)
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12872-024-04193-3
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Harbin Medical University