Prognostic signature and immunotherapeutic relevance of Focal adhesion signaling pathway-related genes in osteosarcoma
Our study validated the prognostic role of three focal adhesion pathway-related genes (ZYX, CAV1, and ITGA5) in patients with osteosarcoma and constructed a prognostic signature model associated with the focal adhesion signaling pathway. We identified significant differences in the expression of multiple immune checkpoint-related genes among subgroups defined by the three genes. Additionally, CD274 and PDCD1LG2 showed higher expression in osteosarcoma cell lines characterized by these genes. These findings may aid in the selection of effective immunotherapy for specific osteosarcoma patients.
Authors
- Wangjun Yan (ORCID: https://orcid.org/0000-0003-1509-6546)
- Yingzheng Ji
- Zhiqiang Wu (ORCID: https://orcid.org/0000-0003-3203-8102)
- Wang Zhi-qing (ORCID: https://orcid.org/0009-0000-7672-1283)
- Zhanqiang Hua
- Qingrong Ye
- Hao Zhang (ORCID: https://orcid.org/0000-0002-9192-4684)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Second Military Medical University (CN)
- Shanghai University of Electric Power (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Electric (China) (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38523
- Citations
- 4
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Shanghai Municipal Health Commission