PPARγ agonist alleviates calcium oxalate nephrolithiasis by regulating mitochondrial dynamics in renal tubular epithelial cell
Our results indicated that increased mitochondrial fission in renal tubular epithelial cells is a critical component of kidney injury caused by calcium oxalate stones, leading to the accumulation of reactive oxygen species within the tissue and the subsequent initiation of apoptosis. Regulating mitochondrial dynamics represents a promising approach for calcium oxalate nephrolithiasis.
Authors
- Xingyang Liu (ORCID: https://orcid.org/0000-0001-9119-8478)
- Xiongfei Liu (ORCID: https://orcid.org/0000-0001-8316-4833)
- Junfa Liu (ORCID: https://orcid.org/0000-0003-0340-9824)
- E Wang (ORCID: https://orcid.org/0000-0001-9463-9769)
- Lizhe Guo (ORCID: https://orcid.org/0000-0002-6131-7840)
- Qian Gao (ORCID: https://orcid.org/0000-0001-8189-6061)
- Zhitao Dong (ORCID: https://orcid.org/0000-0002-8563-2247)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1371/journal.pone.0310947
- Citations
- 4
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- National Science and Technology Planning Project