Non-saponin from Panax ginseng maintains blood-brain barrier integrity by inhibiting NF-κB and p38 MAP kinase signaling pathways to prevent the progression of experimental autoimmune encephalomyelitis
NSs could attenuate movement dysfunctions and related pathological/inflammatory changes by reducing BBB permeability through NF-κB and p38 MAPK pathway inhibition in LSCs of EAE model mice. These are the first results suggesting that NSs can be potential therapeutic agents for MS by reducing BBB permeability.
Authors
- Yujeong Ha (ORCID: https://orcid.org/0000-0002-9109-2240)
- Yoonsung Lee (ORCID: https://orcid.org/0000-0001-9934-2390)
- Sang‐Kwan Moon (ORCID: https://orcid.org/0000-0003-0497-3080)
- Tae Woo Kwon (ORCID: https://orcid.org/0000-0003-2417-9458)
- Ik‐Hyun Cho (ORCID: https://orcid.org/0000-0002-1036-0494)
- Min Soo Kim (ORCID: https://orcid.org/0000-0003-1892-8061)
- Jinhee Oh (ORCID: https://orcid.org/0009-0008-8754-8779)
- Seung-Yeol Nah
- Hyo-Sung Jo
Institutions
- Konkuk University (KR)
- Kyung Hee University (KR)
- Korea Institute of Brain Science (KR)
- Kyung Hee University Medical Center (KR)
- Korean Association Of Science and Technology Studies (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- Korea Institute of Science and Technology (KR)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.jgr.2024.09.005
- Citations
- 3
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea