DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease
DeSUMOylation of RBMX plays a crucial role in determining the makeup of miRNAs in kidney cell exosomes, impacting the protective miRNAs which regulate mitochondrial damage through their interaction with CERS6 mRNA, ultimately affecting mitochondrial health in DKD.
Authors
- Yaoming Xue (ORCID: https://orcid.org/0000-0003-1356-4780)
- Yijie Jia (ORCID: https://orcid.org/0000-0002-4338-8397)
- Zongji Zheng (ORCID: https://orcid.org/0000-0003-0434-0152)
- Wenhui Dong
- Meiping Guan (ORCID: https://orcid.org/0000-0002-9709-9320)
- Junyu Xue
- Shijing Ren
- Haibin Xu
- Xiaomin Li
- Xiangyu Wang
- Yanlin Yang (ORCID: https://orcid.org/0000-0003-4979-1248)
- Ling Wang (ORCID: https://orcid.org/0000-0003-3839-5231)
- Jiayi Luo (ORCID: https://orcid.org/0000-0002-3343-5006)
- Wei He (ORCID: https://orcid.org/0000-0002-3100-9724)
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.jare.2024.09.021
- Citations
- 8
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Natural Science Foundation of Jiangxi Province
- Southern Medical University
- Nanfang Hospital