Antibacterial Activity of Medicinal Plants and the Impact of Isolated Bioactive Compounds against Methicillin Resistant Staphylococcus aureus

<i>Staphylococcus aureus</i> is amongst those microorganisms that have the ability to cause broad-spectrum infections. The bacteria can be both hospital and community-acquired due to the resistance mechanism developed against the available antibiotics. As the bacteria is resistant to almost all β-lactam antibiotic family, its treatment is becoming increasingly difficult. Therefore, new strategies should be implemented to control the pathogen which is fast transforming as a multi-drug resistant (MDR) microorganism. Medicinal plants serve as an alternative candidate to antibiotics due to the medicated efficacy attracting many researchers in the last decade. Several studies are being carried out worldwide to treat this pathogenic bacterium with the active ingredients present in various plant species. This review paper aims to depict the antibacterial activity of different medicinal plants and the impact of the isolated bioactive compounds against the multi-drug resistant (MDR) pathogen-methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and to introspect the mechanism of action of the natural products in interrupting the resistance mechanism of MRSA thereby killing the bacteria