Genetically predicted Caspase 8 levels mediates the causal association between CD4+ T cell and breast cancer
Our study establishes a causal connection linking CD4+ T cells and BC, with Caspase 8 levels partially mediating this relationship. These findings enhance our genetic and molecular comprehension of BC, suggesting potential pathways for future BC immunotherapy drug development.
Authors
- Jinhong Wang
- Zequn Zheng
- Yanbin Chen (ORCID: https://orcid.org/0000-0001-8678-5934)
- Lei Xie
- Xifeng Huang
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3389/fimmu.2024.1410994
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Shantou University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangdong Medical Research Foundation
- Shantou University Medical College