Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study
This study, for the first time, demonstrated that LDA and/or UFH therapies are effective in improving pregnancy outcomes in women with RPL and aβ2GPI/HLA-DR antibody positivity.
Authors
- Gén Kobashi (ORCID: https://orcid.org/0000-0001-7511-9987)
- Kenji Tanimura (ORCID: https://orcid.org/0000-0003-1435-120X)
- Hideto Yamada (ORCID: https://orcid.org/0000-0001-9839-2214)
- Hisashi Arase (ORCID: https://orcid.org/0000-0002-1153-3166)
- Tomoyuki Fujii
- Sayaka Tsuda
- Yosuke Ono (ORCID: https://orcid.org/0000-0001-5540-9434)
- Shigeru Saito
- Mikiya Nakatsuka (ORCID: https://orcid.org/0000-0002-0359-4516)
- Takeshi Nagamatsu
- Masashi Deguchi
Institutions
- Okayama University (JP)
- Teine Keijinkai Hospital (JP)
- Sanno Medical Center (JP)
- University of Toyama (JP)
- Kobe University (JP)
- University of Yamanashi (JP)
- The University of Tokyo (JP)
- Dokkyo Medical University (JP)
- International University of Health and Welfare (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3389/fimmu.2024.1445852
- Citations
- 11
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 2.65
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Moonshot Research and Development Program