Investigating the role and regulation of GPNMB in progranulin-deficient macrophages
These findings highlight the fact that knowledge of early-stage disease mechanism(s) in peripheral populations may inform treatment strategies to delay disease progression at an early, prodromal timepoint prior to development of neuroinflammation and CNS pathology.
Authors
- Malu Gámez Tansey (ORCID: https://orcid.org/0000-0002-1719-4708)
- Rebecca L. Wallings (ORCID: https://orcid.org/0000-0003-0947-4459)
- Drew A. Gillett
- Noelle K. Neighbarger (ORCID: https://orcid.org/0009-0007-6649-0988)
- Cassandra R. Cole
Institutions
- University of Florida (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3389/fimmu.2024.1417836
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- National Institute for Health and Care Research
- National Institute of Neurological Disorders and Stroke