Sphingosine 1-phosphate receptor 2 in keratinocytes plays a key role in reducing inflammation in psoriasis
This study reaches two main conclusions: signals from keratinocytes play a central role in creating an immune environment that promotes the development of psoriasis, and stimulating S1PR2, instead of suppressing it, represents a potential therapeutic approach for psoriasis.
Authors
- Shahrzad Alimohammadi
- Kana Masuda‐Kuroki (ORCID: https://orcid.org/0000-0003-0425-6858)
- Anna Di Nardo (ORCID: https://orcid.org/0000-0002-5575-9968)
- S. F. Lowry
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3389/fimmu.2024.1469829
- Citations
- 3
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Eczema Association
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases