Mendelian randomization analysis and validation supports MEGF9 and MLLT11 as potential targets for the treatment of varicocele and male infertility
In conclusion, this study indirectly supports that varicocele causes MI. BSHXP inhibiting MEGF9 and MLLT11 may become a potential therapeutic target for alleviating varicocele and MI.
Authors
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-4273-821X)
- D. Y. Xing (ORCID: https://orcid.org/0000-0002-5814-781X)
- Weimin Deng (ORCID: https://orcid.org/0000-0001-8592-0268)
- Yihan Jin (ORCID: https://orcid.org/0009-0008-6191-5665)
- Dalin Sun (ORCID: https://orcid.org/0000-0002-1442-9962)
- Hongle Zhao (ORCID: https://orcid.org/0000-0003-2303-6834)
- Baofang Jin (ORCID: https://orcid.org/0000-0002-5604-2897)
- Bin Cai (ORCID: https://orcid.org/0000-0003-1024-7835)
Institutions
- Zhongda Hospital Southeast University (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- Southeast University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3389/fendo.2024.1416384
- Citations
- 2
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Natural Science Foundation of China