Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration
These experiments show that a lack of arrestin-3 is not protective against the abuse liability of morphine in an operant self-administration context. Our data also suggest that opioids that engage both G protein and arrestin-3, recapitulating the endogenous signaling pattern, will reduce abuse liability.
Authors
- Noah Dirks
- Sarah Gooding (ORCID: https://orcid.org/0000-0002-1549-7043)
- Jennifer L. Whistler (ORCID: https://orcid.org/0000-0002-1517-9678)
- Lindsey Felth
- Madeline King
- Randi Foxall (ORCID: https://orcid.org/0000-0003-2396-6695)
- Joshua Gipoor
- Cheryl A. Whistler (ORCID: https://orcid.org/0000-0002-2301-2069)
- Zachary Rosa
- Kyle E. Ireton (ORCID: https://orcid.org/0000-0003-1575-8968)
- Anirudh Gaur (ORCID: https://orcid.org/0000-0001-8558-5594)
- Izabella Sall (ORCID: https://orcid.org/0000-0001-8313-874X)
Institutions
- University of New Hampshire (US)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.3389/fphar.2024.1438037
- Citations
- 5
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.17