Downregulation of PIEZO2 in the Detrusor of Men With Bladder Outlet Obstruction and Its Association With Urinary Retention and Decreased Bladder Compliance
Our findings indicate that PIEZO2 is downregulated in the detrusor muscle of men with BPH, particularly in those experiencing urinary retention and those with reduced BC. These results suggest a potential role for PIEZO2 in BOOinduced bladder dysfunction. Further research is required to clarify the role of PIEZO mechanotransducers in the bladder and to explore their therapeutic implications.
Authors
- William Carlos Nahas (ORCID: https://orcid.org/0000-0002-7395-8370)
- José de Bessa (ORCID: https://orcid.org/0000-0003-4833-4889)
- Ruan Pimenta (ORCID: https://orcid.org/0000-0002-3423-5647)
- Thiago Souto Hemerly
- Carlos Henrique Suzuki Bellucci (ORCID: https://orcid.org/0000-0002-3570-859X)
- Kátia Ramos Moreira Leite (ORCID: https://orcid.org/0000-0002-2615-7730)
- Sabrina T. Reis (ORCID: https://orcid.org/0000-0002-3564-3597)
- Alberto A. Antunes (ORCID: https://orcid.org/0000-0001-7520-8453)
- Cristiano Mendes Gomes (ORCID: https://orcid.org/0000-0002-8486-4003)
- Ettickan Boopathi (ORCID: https://orcid.org/0000-0001-9431-7719)
- Luísa Resende Tenório de Albuquerque (ORCID: https://orcid.org/0000-0002-4348-1321)
- Vanessa Guimarães Schreiter
Institutions
- Thomas Jefferson University (US)
- Universidade de São Paulo (BR)
- Universidade Estadual de Feira de Santana (BR)
Publication Details
- Journal
- International Neurourology Journal
- Published
- 2024-09-26
- DOI
- https://doi.org/10.5213/inj.2448298.149
- Citations
- 2
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- New York State Department of Health
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Universidade de São Paulo
- National Institutes of Health