Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds
An eco-friendly electrochemical halogenation of 2-amino-1,4-naphthoquinones has been developed. The new mild and energy efficient methodology comprises sustainable features like oxidant free and double role of the halogen source as electrolyte, originating twenty-six amino-halogenated naphthoquinoidal derivatives in good yields under mild conditions. This novel methodology permitted access to new potent trypanocidal prototypes, where six compounds were more active than benznidazole, the current market drug used in the treatment of Chagas Disease.
Authors
- Rubem F. S. Menna‐Barreto (ORCID: https://orcid.org/0000-0002-1352-0641)
- Maria H. Araújo (ORCID: https://orcid.org/0000-0002-2609-0281)
- Emilay B. T. Diogo
- Claudia C. Gatto (ORCID: https://orcid.org/0000-0002-3736-6861)
- Renata G. Almeida (ORCID: https://orcid.org/0000-0003-2896-0487)
- Guilherme A. M. Jardim (ORCID: https://orcid.org/0000-0002-9882-3085)
- Eufrânio N. da Silva Júnior (ORCID: https://orcid.org/0000-0003-1281-5453)
- Gabriela A. P. Graça (ORCID: https://orcid.org/0000-0001-9114-8016)
- Caren D. G. da Silva (ORCID: https://orcid.org/0000-0003-1685-6316)
- Eduardo F. S. Guimarães
- Victor F. S. Ramos
- Daiane B. Pereira
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade de Brasília (BR)
- Faculdades Oswaldo Cruz (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1002/asia.202401050
- Citations
- 5
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 1.75