Modulatory Effect of Ginseng Extracts against Trafos Cu Plant Growth Regulators Induced Renal Toxicity in Rats

Background: Plant growth regulators (PGRs) are widely used as pesticides that can induce toxicity to industrial workers and farmers directly by inhalation during use in agriculture and indirectly through food that have been sprayed with PGRs. Therefore, this work intends to investigate the protective and therapeutic effects of ginseng extracts against Trafos Cu induced kidney toxicity, DNA fragmentation, oxidative stress, and PCNA expression alterations. Methods: A total of 60 male rats divided into 6 groups [Gp1, control; Gp2, ginseng; Gp3, Trafos Cu; Gp4, Ginseng+ Trafos Cu; Gp5, Trafos Cu+Ginseng; Gp6, Self-treated. Result: Current findings revealed that rats treated with Trafos Cu (Gp3 and Gp6) induced a significant elevation in serum urea, creatinine, sodium, potassium, chloride and renal injury, DNA damage, MDA, PCNA, TNFα expressed and a significant depletion in calcium, GSH, and catalase levels as compared to control. Treatments of Trafos Cu with Ginseng (Gp4 and Gp5) induced improvements in kidney functions and structure with best results for Gp5. Ginseng has the capacity to mitigate the renal toxicity induced by Trafos Cu in male albino rats.