Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models
This is the first study to comprehensively demonstrate an essential and unique role of PKN1 in cerebral energy metabolism, regulating glycolysis and mitochondrial pyruvate-induced respiration. We further uncovered a highly protective phenotype of Pkn1 deficiency in both, in vitro and in vivo stroke models, validating inhibition of PKN1 as a promising new therapeutic target for the development of novel stroke therapies.
Authors
- Anne Krogsdam (ORCID: https://orcid.org/0000-0002-5478-0511)
- Cyrille Orset (ORCID: https://orcid.org/0000-0002-9139-3430)
- Bettina Sarg (ORCID: https://orcid.org/0000-0002-4785-8739)
- Stephanie zur Nedden (ORCID: https://orcid.org/0000-0002-2111-0757)
- Angus J.M. Cameron (ORCID: https://orcid.org/0000-0003-3906-2789)
- Ira Skvortsova (ORCID: https://orcid.org/0000-0001-8993-611X)
- Gottfried Baier (ORCID: https://orcid.org/0000-0002-2085-8325)
- Dragana Savic (ORCID: https://orcid.org/0000-0001-5196-4676)
- Herbert Oberacher (ORCID: https://orcid.org/0000-0002-0963-8268)
- Sandro Carollo
- Madlen Hotze (ORCID: https://orcid.org/0009-0001-1816-2089)
- Motahareh Solina Safari
- Zlatko Trajanoski (ORCID: https://orcid.org/0000-0002-0636-7351)
- Marcel Kwiatkowski (ORCID: https://orcid.org/0000-0002-5804-6031)
- Klaus Faserl (ORCID: https://orcid.org/0000-0003-1646-3256)
- Carolin Garmsiri
- Louisa Kuenkel (ORCID: https://orcid.org/0009-0001-4754-182X)
- Florian Ostermaier
- Dominik Zlotek
- Benoît Haelewyn
- L. Láng
- Dido Weber
- Tom Freret
Institutions
- Innsbruck Medical University (AT)
- Inserm (FR)
- Queen Mary University of London (GB)
- Universität Innsbruck (AT)
- Tyrolean Cancer Research Institute (AT)
- Normandie Université (FR)
- Cyceron (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Metabolism
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.metabol.2024.156039
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Austrian Science Fund