Evaluation and application of population pharmacokinetic models for optimising linezolid treatment in non-adherence multidrug-resistant tuberculosis patients
Monte Carlo simulations based on popPK models can propose remedial regimens for delayed doses of linezolid in patients with MDR-TB. Model-based compliance management patterns are useful for balancing efficacy, adverse reactions, and resistance suppression.
Authors
- Yuanbo Lan
- Junjun Mao (ORCID: https://orcid.org/0000-0003-4219-5953)
- Zhen Feng (ORCID: https://orcid.org/0000-0003-1281-4522)
- Yang Li (ORCID: https://orcid.org/0000-0003-4022-7341)
- Hongying Yu (ORCID: https://orcid.org/0000-0001-5510-9407)
- Yilin Zhang (ORCID: https://orcid.org/0000-0001-5350-8279)
- Rong Li (ORCID: https://orcid.org/0009-0001-0410-5681)
- Wenhong Zhang (ORCID: https://orcid.org/0000-0002-9682-827X)
- Feng Sun (ORCID: https://orcid.org/0000-0002-8413-5177)
Institutions
- Huashan Hospital (CN)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1016/j.ejps.2024.106915
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.34