Qin-Yu-Qing-Chang decoction reshapes colonic metabolism by activating PPAR-γ signaling to inhibit facultative anaerobes against DSS-induced colitis
In summary, QYQC ameliorates UC by activating PPAR-γ signaling and increasing the proportion of PPAR-γ entering the nucleus, which enhances the energy metabolism of intestinal epithelial cells and thereby preventing the uncontrolled proliferation of facultative anaerobes.
Authors
- Hong Shen (ORCID: https://orcid.org/0000-0003-1878-7334)
- Ryan Au (ORCID: https://orcid.org/0000-0002-0162-7660)
- Yulai Fang (ORCID: https://orcid.org/0009-0006-0309-6070)
- Feng Xu (ORCID: https://orcid.org/0000-0002-8102-3903)
- Yiheng Tong (ORCID: https://orcid.org/0000-0002-5779-1734)
- Cheng Cheng (ORCID: https://orcid.org/0000-0002-5947-3414)
- Lei Zhu (ORCID: https://orcid.org/0009-0004-3602-1281)
- Yuguang Wu
- Yuan Cui (ORCID: https://orcid.org/0000-0003-2118-5705)
- Hongxin Chen (ORCID: https://orcid.org/0000-0002-1512-3666)
- Jingyi Hu (ORCID: https://orcid.org/0000-0001-7726-6753)
- Yanan Li (ORCID: https://orcid.org/0000-0003-4396-0557)
Institutions
- Zhejiang Chinese Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Academy of Chinese Culture and Health Sciences (US)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1186/s13020-024-01006-9
- Citations
- 8
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.87