Metabolomics integrated with network pharmacology of blood-entry constituents reveals the bioactive component of Xuefu Zhuyu decoction and its angiogenic effects in treating traumatic brain injury
By applying a novel strategy of integrating network pharmacology of constituents absorbed in blood with metabolomics, the research screened HSYA as one of the top bioactive constituents of XFZYD, which stimulates angiogenesis by activating the PI3K/Akt/mTOR signaling pathway after TBI.
Authors
- Quan Chen (ORCID: https://orcid.org/0000-0001-7539-8728)
- En Hu (ORCID: https://orcid.org/0000-0003-1091-2233)
- Zhe Yu (ORCID: https://orcid.org/0009-0009-1370-6954)
- Tao Tang (ORCID: https://orcid.org/0000-0001-7838-8525)
- Jiekun Luo (ORCID: https://orcid.org/0000-0002-9622-533X)
- Lianglin Zhang
- Yang Wang (ORCID: https://orcid.org/0000-0003-0447-3107)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-4375-0368)
- Xin Guo (ORCID: https://orcid.org/0009-0003-3414-8564)
- Menghan Cheng
- Teng Li (ORCID: https://orcid.org/0000-0002-0537-8008)
- Qiuju Yan
- Haigang Li (ORCID: https://orcid.org/0000-0003-2346-6527)
- Fei Zheng (ORCID: https://orcid.org/0000-0002-6150-5892)
- Weikang Luo (ORCID: https://orcid.org/0000-0002-1354-634X)
- Hong Su (ORCID: https://orcid.org/0009-0003-7978-6359)
- Yao Wu (ORCID: https://orcid.org/0009-0001-5919-4757)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Changsha Medical University (CN)
- Xiangyang Central Hospital (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1186/s13020-024-01001-0
- Citations
- 40
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 28.65
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hunan Province
- Key Research and Development Program of Hunan Province of China