Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors
A pan-cancer analysis was performed on three cancers, BCC, MA, and HNSCC, focusing on tumor fibroblasts in TME. Unsupervised clustering categorized CAF into nine subpopulations, among which the C0 subpopulation had a strong correspondence with BCC-CAF and an invasive- destructive-related phenotype.
Authors
- Gang Chai (ORCID: https://orcid.org/0000-0002-8311-2520)
- Wenjing Xi
- Byeong Seop Kim
- Mengyuan Hou
- Li Li (ORCID: https://orcid.org/0000-0003-4101-3759)
- Yichi Zhang (ORCID: https://orcid.org/0000-0002-2280-7599)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-8196-9440)
- Lin Li (ORCID: https://orcid.org/0000-0003-4597-2017)
- Xin Li (ORCID: https://orcid.org/0000-0001-6432-3966)
- Wenyi Huang (ORCID: https://orcid.org/0009-0007-2999-5362)
- Zhijie Zhao
Institutions
- Shanghai University (CN)
- Shanghai Jiao Tong University (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Current Gene Therapy
- Published
- 2024-09-26
- DOI
- https://doi.org/10.2174/0115665232331353240911080642
- Citations
- 47
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 13.28