In silico Discovery of Leptukalins, The New Potassium Channel Blockers from the Iranian Scorpion, Hemiscorpius Lepturus

Three non-toxic KTxs, Leptukalin 3, 5, and 7, were successfully discovered from the cDNA library of <i>H. lepturus</i> venom gland. Gathering all data together, the discovered peptides are promising potassium channel blockers. Accordingly, Leptukalin 3, 5, and 7 could be suggested for complementary in vitro studies and mouse model of autoimmune diseases.

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Publication Details

Journal
Current Computer - Aided Drug Design
Published
2024-09-26
DOI
https://doi.org/10.2174/0115734099309285240912113303
Citations
1
Primary Topic
Venomous Animal Envenomation and Studies
Type
article
Field-Weighted Citation Impact
0.55
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article

In silico Discovery of Leptukalins, The New Potassium Channel Blockers from the Iranian Scorpion, Hemiscorpius Lepturus

Hasan Mirzahoseini, Kamran Pooshang Bagheri, Maryam Khalili-Salmasi, Ahmad Nazarian et al.
1 citations
Current Computer - Aided Drug Design
Venomous Animal Envenomation and Studies
0.55
article

In silico Discovery of Leptukalins, The New Potassium Channel Blockers from the Iranian Scorpion, Hemiscorpius Lepturus

Hasan Mirzahoseini, Kamran Pooshang Bagheri, Maryam Khalili-Salmasi, Ahmad Nazarian, Amir Amirkhani
article en
1 citations

Abstract

Three non-toxic KTxs, Leptukalin 3, 5, and 7, were successfully discovered from the cDNA library of <i>H. lepturus</i> venom gland. Gathering all data together, the discovered peptides are promising potassium channel blockers. Accordingly, Leptukalin 3, 5, and 7 could be suggested for complementary in vitro studies and mouse model of autoimmune diseases.

Current Computer - Aided Drug DesignVol. 21(8)
Pasteur Institute of Iran (IR), Biotechnology Research Center (IR)
Openalex Percentile: Top 26%
Venomous Animal Envenomation and Studies
0.55
DOISourceOpenAlex
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In silico Discovery of Leptukalins, The New Potassium Channel Blockers from the Iranian Scorpion, Hemiscorpius Lepturus — Hasan Mirzahoseini, Kamran Pooshang Bagheri, et al. · Current Computer - Aided Drug Design (2024) | TGRS Research Map | TGRS