Disulfiram-Copper Potentiates Anticancer Efficacy of Standard Chemotherapy Drugs in Bladder Cancer Animal Model through ROS-Autophagy-Ferroptosis Signalling Cascade
It was found that disulfiram with copper treatment inhibits bladder tumour growth through ferroptosis- mediated ROS induction, which further activates the process of autophagy. Our results prove that DSF-Cu can be an effective add-on therapy along with the standard chemotherapy drugs for the treatment of UBC.
Authors
- Ritika Panwar
- Neeru M. Sharma (ORCID: https://orcid.org/0000-0002-8477-7065)
- Ravimohan S. Mavuduru (ORCID: https://orcid.org/0000-0003-1369-7479)
- Ashish Kumar Kakkar (ORCID: https://orcid.org/0000-0001-7768-7304)
- Smita Pattanaik (ORCID: https://orcid.org/0000-0002-5548-4685)
- Monidipa Konar
- Sandeep Kumar (ORCID: https://orcid.org/0000-0001-9461-6065)
- Priyanka Naithani (ORCID: https://orcid.org/0009-0008-8602-4367)
- Sheetal Singh
- Sumit Dey (ORCID: https://orcid.org/0000-0001-7331-6661)
- Pulkit Rastogi
Institutions
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2024-09-26
- DOI
- https://doi.org/10.2174/0115680096325879240815105227
- Citations
- 6
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.71