Effect of Aloe Vera against Natural and Chemical Toxicities

Aloe vera (<i>A. barbadensis</i>, <i>A. indica</i>, and <i>Aloe vulgaris</i>) is a succulent plant native to the southeast Arabian Peninsula. Yet it’s been cultivated all over the world with widespread use in skin products due to its natural anti-inflammatory effects because it contains alkaline phosphatases, brady kinases, catalases, and antioxidant effects due to its high concentration of vitamin A and E. Aloe vera has shown some anti-TNF-α and anti-TGF-β properties as well. It also has anti-oxidative stress effects against many toxins. This review focuses on many <i>in-vitro or in vivo</i> studies on numerous toxins, either natural or synthetic, and the role that Aloe vera can play in ameliorating their effects. Aloe vera has consistently been shown to affect the MDA, GSH, and other reduction- oxidation pathways in the cell. It has been shown to improve cell-free radical scavenging applications and be a natural, safe, and cheap supplement to treat many toxins and toxicants.