Toll-like receptor 4 damages the intestinal epithelial cells by activating endoplasmic reticulum stress in septic rats
We concluded that the inhibition of TLR4/NF-κB signaling pathway can reduce intestinal inflammatory response, protect intestinal mucosa, protect Lgr5+ cells, goblet cells and relieve ER stress. Our findings suggest that Tak-242 protects Lgr5+ cells and goblet cells after sepsis, partly may be through the suppression of ER stress. Thus, inhibition of TLR4-mediated ER stress may be a promising therapy of septic AGI.
Authors
- Ji-Lin Yang
- Xin Bao (ORCID: https://orcid.org/0009-0006-3065-3194)
- Yijie Wang (ORCID: https://orcid.org/0000-0002-0986-4644)
- Xue Wu (ORCID: https://orcid.org/0000-0003-3394-5409)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-09-26
- DOI
- https://doi.org/10.7717/peerj.18185
- Citations
- 7
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.28
Funders
- National Natural Science Foundation of China
- Kunming Medical University
- Yunnan Provincial Science and Technology Department
- NIH Clinical Center