Deciphering regulatory patterns in a mouse model of hyperoxia-induced acute lung injury
Our results provide new insights into the potential mechanisms and underlying pathogenesis in the development of HALI at the post-transcriptional level. The findings of this study reveal potential regulatory interactions and biological roles of specific lncRNAs and genes, such as H19 and Sox9, encompassing driven gene expression patterns, alternative splicing events, and lncRNA-miRNA-mRNA ceRNA networks. These findings may pave the way for advancing therapeutic strategies and reducing the risk associated with oxygen treatment for patients.
Authors
- Xinyang Huang (ORCID: https://orcid.org/0000-0002-6100-377X)
- Jinwen Liu (ORCID: https://orcid.org/0000-0003-2823-0396)
- Yundi Chen
- Qin Han (ORCID: https://orcid.org/0000-0002-7317-0823)
- Song Qin (ORCID: https://orcid.org/0000-0001-7079-596X)
- Chunyan Wei
- Xiaolin Hu
Institutions
- Zunyi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- First People’s Hospital of Zunyi (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-09-26
- DOI
- https://doi.org/10.7717/peerj.18069
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- School of Medicine, Shanghai Jiao Tong University