Electrocardiographic Evaluation the Effect of Thiamine Hydrochloride on Triton X-100 Induced Hyperlipidemia in Rats

Aim: Hyperlipidemia, a prevalent condition globally, contributes significantly to cardiovascular diseases. This research focuses on the impacts of thiamine hydrochloride on lipid profiles and ECG changes in rats with Triton X-100 induced hyperlipidemia. Materials and Methods: A total of eighteen male Wistar Albino rats were divided into three groups: control, Triton X-100, and Triton X-100 + Thiamine. To induce hyperlipidemia, Triton X-100 was administered as a single intraperitoneal dose of 100 mg/kg. Thiamine hydrochloride was then given intraperitoneally at a dose of 25 mg/kg daily for 7 days, starting 72 hours after the induction of hyperlipidemia. ECG data were recorded, and serum biochemical parameters were analyzed. Results: Thiamine treatment significantly reduced elevated total cholesterol and triglyceride levels induced by Triton X-100. It also improved the coronary risk index and normalized ECG characteristics include the heart rate and the RR interval. ECG abnormalities, including ST segment elevation and atrial fibrillation, were less frequent in the thiamine-treated group. Conclusion: Thiamine hydrochloride effectively mitigates hyperlipidemia and its associated cardiovascular risks, suggesting its potential as a therapeutic agent. Further research is needed to explore its clinical applications in managing dyslipidemia and cardiovascular diseases.