Cirrhosis of Liver in Ayurveda With Special Reference to Yakrit Vikara

Introduction :Liver disorders include varied spectrum of disorders which includes all the conditions from acute to chronic . The liver disorders include viral hepatitis, cirrhosis , chronic liver disease, metabolic liver disease, liver cancer etc. Cirrhosis, called "Yakrit vriddhi" in Ayurveda often associated with imbalance in pitta Dosha mainly effects metabolism and digestion. Cirrhosis is a chronic liver disease characterized by widespread fibrosis and nodular regeneration that disrupts the liver's structure and function, often resulting from chronic liver injury. Methods :Compilation of information is done by using Relevant textbooks on the clinical pathophysiology of liver disorders and databases such as PubMed, Google Scholar, Scopus. Result : Cirrhosis is a significant global health issue, contributing to substantial morbidity and mortality. The incidence and prevalence vary widely across regions due to differences in underlying causes such as viral hepatitis, alcohol consumption patterns, and healthcare access. The pathophysiology of liver cirrhosis in Ayurveda includes Pitta-induced inflammation and fibrosis in the liver, obstructing bile flow and impairing detoxification. This causes tissue damage (dhatu kshaya) and liver dysfunction. Discussion :Cirrhosis of liver is a chronic disease in which there is diffuse destruction and fibrotic regeneration. Multiple cells play a role in liver cirrhosis, including hepatocytes and sinusoidal lining cells such as hepatic stellate cells (HSCs), sinusoidal endothelial cells (SECs), and Kupffer cells (KCs). Symptoms of cirrhosis vary depending on the stage of diagnosis, effectiveness of treatment, and patient compliance. . Diagnostic approaches include imaging studies, liver function tests, and liver biopsy. Management involves treating underlying causes, managing complications, and considering liver transplantation in advanced cases.Ayurvedic management of cirrhosis focus on pacifying aggravated Pitta Dosha through many herbs and rasoushadhi which aids for detoxification and have Rasayana effect on liver.