The Effectiveness of Ascorbic Acid or Ascorbic Acid–Containing Food Intervention in the Treatment of Existing Xerostomia in the Adult Population

The objective of this review was to assess the efficacy of vitamin C or vitamin C–containing foods in adults with existing xerostomia. Vitamin C and food containing vitamin C could significantly improve xerostomia, which is important since there is an association between xerostomia, inadequate oral intake, and malnutrition. After a literature review, a total of 202 articles were screened. Two randomized controlled trials and 2 nonrandomized crossover trials met inclusion criteria. Limited evidence indicated improved quality of life, oral intake, and markers of xerostomia. Vitamin C was safe and well tolerated. Additional studies are needed to determine clinical efficacy.