Intrapatient Intermetastatic Heterogeneity Determined by Triple-Tracer PET Imaging in mCRPC Patients and Correlation to Survival: The 3TMPO Cohort Study
Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine the prevalence of IIH and RPT eligibility in mCRPC patients through a triple-tracer PET imaging strategy. <b>Methods:</b> This was a multisite prospective observational study in which mCRPC patients underwent both <sup>18</sup>F-FDG and <sup>68</sup>Ga-prostate-specific membrane antigen (PSMA)-617 PET/CT scans. A third scan with <sup>68</sup>Ga-DOTATATE, a potential biomarker of neuroendocrine differentiation, was performed if an <sup>18</sup>F-FDG-positive/<sup>68</sup>Ga-PSMA-negative lesion was found. Per-tracer lesion positivity was defined as having an uptake at least 50% above that of the liver. IIH prevalence was defined as the percentage of participants having at least 2 lesions with discordant features on multitracer PET. <b>Results:</b> IIH was observed in 81 patients (82.7%), and at least 1 <sup>18</sup>F-FDG-positive/<sup>68</sup>Ga-PSMA-negative lesion was found in 45 patients (45.9%). Of the 37 participants who also underwent <sup>68</sup>Ga-DOTATATE PET/CT, 6 (16.2%) had at least 1 <sup>68</sup>Ga-DOTATATE-positive lesion. In total, 12 different combinations of lesion imaging phenotypes were observed. On the basis of our prespecified criteria, 52 (53.1%) participants were determined to be eligible for PSMA RPT, but none for DOTATATE RPT. Patients with IIH had a significantly shorter median overall survival than patients without IIH (9.5 mo vs. not reached; log-rank <i>P</i> = 0.03; hazard ratio, 2.7; 95% CI, 1.1-6.8). <b>Conclusion:</b> Most mCRPC patients showed IIH, which was associated with shorter overall survival. On the basis of a triple-tracer PET approach, multiple phenotypic combinations were found. Correlation of these imaging phenotypes with genomics and treatment response will be relevant for precision medicine.
Authors
- Éric Lévesque (ORCID: https://orcid.org/0000-0001-5986-3458)
- Brigitte Guérin (ORCID: https://orcid.org/0000-0002-0319-4512)
- Stephan Probst (ORCID: https://orcid.org/0000-0002-8692-7573)
- Zineb Hamilou (ORCID: https://orcid.org/0009-0004-2096-8307)
- Catherine Allard (ORCID: https://orcid.org/0000-0002-8829-4984)
- Jean‐François Castilloux
- Frédéric Pouliot (ORCID: https://orcid.org/0000-0002-6651-1079)
- Michele Lodde (ORCID: https://orcid.org/0000-0001-8813-318X)
- Fred Saad (ORCID: https://orcid.org/0000-0003-2986-5617)
- François-Alexandre Buteau
- Guillaume F. Bouvet (ORCID: https://orcid.org/0000-0002-7831-9797)
- Patrick O. Richard (ORCID: https://orcid.org/0000-0002-8904-8873)
- Daniel Juneau (ORCID: https://orcid.org/0000-0001-8575-1556)
- Jean‐Baptiste Lattouf (ORCID: https://orcid.org/0000-0002-8192-0508)
- Bertrand Neveu (ORCID: https://orcid.org/0000-0002-6505-6692)
- Jean‐Mathieu Beauregard (ORCID: https://orcid.org/0000-0003-2123-145X)
- Vincent Castonguay (ORCID: https://orcid.org/0000-0001-8053-4026)
- Michel Pavic (ORCID: https://orcid.org/0000-0002-7057-7492)
- Nicolas Marcoux (ORCID: https://orcid.org/0000-0003-1422-6716)
- Atefeh Zamanian (ORCID: https://orcid.org/0009-0006-4243-2567)
- Étienne Rousseau (ORCID: https://orcid.org/0000-0002-2394-7446)
- Amélie Têtu (ORCID: https://orcid.org/0000-0002-9220-1090)
Institutions
- Université de Sherbrooke (CA)
- Jewish General Hospital (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Université Laval (CA)
Publication Details
- Journal
- Journal of Nuclear Medicine
- Published
- 2024-09-26
- DOI
- https://doi.org/10.2967/jnumed.124.268020
- Citations
- 23
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 9.64