Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability
Our findings uncover a novel role of Rap1A in regulating Orai1-mediated Ca<sup>2+</sup> entry and expression, crucial for NFAT-mediated transcription and endothelial inflammation. This study distinguishes the unique function of Rap1A from that of the predominant Rap1B isoform and highlights the importance of normalizing Orai1 expression in maintaining lung vascular integrity and modulating endothelial functions.
Authors
- Ramoji Kosuru (ORCID: https://orcid.org/0000-0002-7394-7217)
- David X. Zhang (ORCID: https://orcid.org/0000-0002-4543-7594)
- Akiko Mammoto (ORCID: https://orcid.org/0000-0003-3448-7331)
- Olivier Romito
- Christian J. Kastrup (ORCID: https://orcid.org/0000-0003-3644-0019)
- Paul H. Goldspink (ORCID: https://orcid.org/0000-0003-1817-4941)
- Francesca Ferraresso
- Tadanori Mammoto (ORCID: https://orcid.org/0009-0002-0985-0856)
- Guru Prasad Sharma (ORCID: https://orcid.org/0000-0003-3197-4396)
- Mohamed Trebak (ORCID: https://orcid.org/0000-0001-6759-864X)
- Magdalena Chrzanowska‐Wodnicka (ORCID: https://orcid.org/0000-0003-4182-2126)
- Kai Yang (ORCID: https://orcid.org/0000-0002-9966-1380)
- Behshid Ghadrdoost Nakhchi
Institutions
- University of Pittsburgh (US)
- Medical College of Wisconsin (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Versiti Blood Center of Wisconsin (US)
- UPMC Hillman Cancer Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1161/atvbaha.124.321458
- Citations
- 10
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 3.61