Room Temperature Regioselective Debenzylative Cycloetherification Reaction
A regio- and stereoselective debenzylative cycloetherification (DBCE) reaction of protected hexoses to form stereodefined hydroxylated tetrahydrofurans of synthetic utility has been investigated under very mild room temperature reaction conditions. This study revealed the potential application of the DBCE reaction of simple, abundant starting materials to access stereochemically rich tetrahydrofuran compounds under mild reaction conditions.
Authors
- Colin D. McMillen (ORCID: https://orcid.org/0000-0002-7773-8797)
- Samuel Kwain (ORCID: https://orcid.org/0000-0002-4065-2025)
- Daniel C. Whitehead (ORCID: https://orcid.org/0009-0005-7590-5941)
Institutions
- Clemson University (US)
Publication Details
- Journal
- ACS Omega
- Published
- 2024-09-26
- DOI
- https://doi.org/10.1021/acsomega.4c04016
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences