STM2457 Inhibits METTL3-Mediated m6A Modification of miR-30c to Alleviate Spinal Cord Injury by Inducing the ATG5-Mediated Autophagy
STM2457 alleviated SCI by suppressing METTL3-mediated m6A modification of miR-30c, which in turn induces ATG5-mediated autophagy. This study provides insights into the role of m6A modification in SCI and suggests a potential therapeutic approach through targeting METTL3.
Authors
- Wenge Liu (ORCID: https://orcid.org/0000-0002-3538-1646)
- Jiandong Li (ORCID: https://orcid.org/0000-0003-3125-5447)
- Zhitao Shangguan (ORCID: https://orcid.org/0000-0002-7669-1915)
- Zhongcan Chen (ORCID: https://orcid.org/0000-0003-0099-0916)
- Gang Chen (ORCID: https://orcid.org/0000-0002-2161-2896)
- Xiaoqing Ye
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Neurospine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.14245/ns.2448494.247
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China