Fabrication and in vitro biocompatibility of hierarchical cellulose acetate/polyvinylpyrrolidone@titania nanowire hollow microfibers
In this study, hierarchical cellulose acetate/polyvinylpyrrolidone hollow microfibers (CA/PVP HMFs) were first prepared via a dip coating method using a steel wire as tubular template and then supported a sol-gel deposition of titania nanoparticles (NPs) to derive CA/PVP@titania NP HMFs. After hydrothermally treated in NaOH solution, CA/PVP@titania NP HMFs were transformed to CA/PVP@titania nanowire (NW) HMFs. SEM observation showed that CA/PVP@titania NW HMFs had a hollow structure with diameters of 450-600 μm and exhibited a hierarchical and nanofibrous structure. Their surfaces were constructed by numerous titania NWs with diameters of 10-30 nm and lengths of 1-5 μm. The incorporation of PVP not only caused a significant change in surface wettability from hydrophobic CA HMFs to hydrophilic CA/PVP HMFs, but also promoted the sol-gel deposition of titania NPs on CA/PVP HMFs. CA/PVP@titania NW HMFs exhibited the highest hydrophilicity with water contact angle of 32° and the largest specific surface area of 86.1 m<sup>2</sup>/g. In vitro biocompatible evaluation indicated that CA/PVP@titania NW HMFs exhibited much higher cell adhesion and proliferation than CA/PVP@titania NP HMFs and CA/PVP HMFs within 7 days due to the presence of nanofibrous surface architecture. Thus, the present CA/PVP titania NW HMFs have potential as biocompatible cell supporting matrices.
Authors
- Tingting Wu (ORCID: https://orcid.org/0000-0002-4653-8493)
- Chen Song (ORCID: https://orcid.org/0000-0001-9373-5302)
- Ren Guo
- Hao Li (ORCID: https://orcid.org/0000-0003-1170-0507)
- Jie Zhao (ORCID: https://orcid.org/0000-0003-0518-4155)
- Like Cao
- Meiwen An
- Jinfeng Liu (ORCID: https://orcid.org/0000-0003-0946-3979)
- Weiyi Chen (ORCID: https://orcid.org/0000-0003-1702-5653)
Institutions
- Second People 's Hospital of Jinzhong (CN)
- Taiyuan University of Science and Technology (CN)
- Taiyuan University of Technology (CN)
Publication Details
- Journal
- International Journal of Biological Macromolecules
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.ijbiomac.2024.136095
- Citations
- 3
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- Natural Science Foundation of Shanxi Province