Highly sensitive and accurate detection of ALK-TKI resistance mutations by oligoribonucleotide interference-PCR (ORNi-PCR)-based methods
ORNi-PCR followed by ddPCR/real-time PCR enables highly sensitive and accurate detection of ALK mutations by liquid biopsy. Although the clinical data are limited, our results show that these methods are potentially useful for identifying ALK-TKI-resistant NSCLC at the early recurrent phase.
Authors
- Hisashi Tanaka (ORCID: https://orcid.org/0000-0003-2009-0210)
- Tomonori Makiguchi (ORCID: https://orcid.org/0000-0001-9249-7904)
- Chiori Tabe (ORCID: https://orcid.org/0000-0001-9022-8700)
- Sadatomo Tasaka (ORCID: https://orcid.org/0000-0003-4861-4143)
- Hodaka Fujii (ORCID: https://orcid.org/0000-0003-1296-4256)
- Kageaki Taima
- Masamichi Itoga (ORCID: https://orcid.org/0000-0002-9400-5245)
- Yoshiko Ishioka (ORCID: https://orcid.org/0000-0001-5312-1314)
- Toshitsugu Fujita (ORCID: https://orcid.org/0000-0002-9536-9999)
Institutions
- Hirosaki University (JP)
Publication Details
- Journal
- Lung Cancer
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.lungcan.2024.107969
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Hirosaki University